Aniella Abi-Gerges, PhD
Associate Professor
Physiology Discipline Coordinator
Medical Ethics Discipline Coordinator
Director of Medical Year 2
Dr. Aniella Abi-Gerges is an Associate Professor of Physiology and the director of Medical Year 2 at the LAU Gilbert and Rose-Marie Chagoury School of Medicine in Byblos. She holds a Ph.D. in Cellular, Molecular and Cardiac Physiopathology with the highest level of distinction from the School of Pharmacy at University Paris 11 in France. During her doctoral training in the Laboratory of Excellence in Drug Discovery and Therapeutic Innovation (Labex LERMIT, Paris), she acquired solid expertise in cardiac pathophysiology and the ß-adrenergic/cAMP signaling pathway. Using an innovative electrophysiological approach based on the use of cyclic nucleotide-gated channels as a cAMP probe, she showed for the first time in real time and in isolated, living cardiac myocytes that cAMP homeostasis is altered in cardiac hypertrophy.
She further developed her knowledge of cardiovascular physiology and hormonal signaling by joining the School of Medicine at Pierre and Marie Curie University in Paris as a post-doctoral fellow for three years, during which she explored the role of the Multidrug- Resistant Protein Type 4 (MRP4) in cardiac function using a knock-out mice model.
Dr. Abi-Gerges joined the school of medicine as a full-time faculty member in September 2016. She has established her academic career on strong foundations of scientific research, medical education, and scholarly activities. She is a proud fellow of the LAU Center for Innovating Learning Faculty (CIL). Her major educational focus is to develop, coordinate and teach physiology to first- and second- year medical students within a challenging integrated medical curriculum.
After completing a University diploma in Medical Ethics at the Lebanese University, Faculty of Medicine in 2019, she designed and developed the Medical Ethics curriculum for Med I and Med II, which she coordinates and teaches as well. Her didactic approach to medical ethics is based on challenging students with debates of ethical dilemmas and roleplaying in order to strengthen their critical thinking and communication skills, respectively.
Her research interests focus mainly on cardiopulmonary diseases and their risk factors, and specifically towards understanding the pathophysiology of diabetic cardiomyopathy (DCM), its progression and therefore its treatment through the identification of new therapeutic targets. She is the founder and leader of a dynamic and active research team “Cellular and Molecular Cardiac Physiopathology” which is comprised of postdoctoral fellows, master students, and research assistants at the LAUSOM. She has developed pathological animal models for type 1 and type 2 diabetes and utilized functional and molecular approaches to characterize specific alterations affecting cardiac Cyclic Adenosine 3′-5′ Monophosphate (cAMP) and calcium signaling pathways in DCM. To implement and develop her research work, she successfully secured intramural, national and international funds as Principal Investigator (PI) and co-PI. Additionally, she fostered strong collaborations with colleagues at LAU through the establishment of interdisciplinary research clusters, which she is either leading or co-leading, as well as with experts in the field of cardiovascular diseases in Lebanon and France. Her research work was featured in intramural, national and international venues and conferences. She was also invited to present her research work as a speaker in national and international scientific symposiums.
In parallel to her main research line on DCM, she developed interests in Medical Ethics research in an effort to resonate with her Medical Ethics course teaching. She is also engaged in research topics focusing on public health and gender in collaboration with the LAU Arab Institute for Women (AiW).
Dr. Abi-Gerges is the author of several publications in international high-impact-factor journals. She serves as a reviewer for international peer-reviewed journals and national research councils. She is currently an active member of the LAU Institutional Review Board (IRB) and the vice chair of the Institutional Animal Care & Use Committee (IACUC). She participated in drafting institutional policies and responsibilities pertaining to animal protection and welfare and use of animal lab medication.
Selected Publications
- Michelle Cherfane, Myriam Boueri, Elio Issa, Racha Abdallah, Ali Hamam, Kassem Sbeity, Anthony Saad, Aniella Abi-Gerges. Unveiling the unseen toll: exploring the impact of the Lebanese economic crisis on the health-seeking behaviors in a sample of patients with diabetes and hypertension. BMC Public Health (2024) 24(1):628.
- Victoria Chaoul, Rita Hanna, Pia Hachem, Magali Samia El Hayek, Wared Nour-Eldine, Pamela Abou-Khalil, Elias Abi-Ramia, Grégoire Vandecasteele, Aniella Abi-Gerges. Differential changes in cyclic adenosine 3′-5′ monophosphate (cAMP) effectors and major Ca2+ handling proteins during diabetic cardiomyopathy (DCM). Journal of Cellular and Molecular Medicine (2023) 27(9):1277-1289.
- Mary Deeb, Dana Alameddine, Rasha Abi Radi Abou Jaoudeh, Widian Laoun, Julian Maamari, Rawan Honeini, Alain Khouri, Fadi Abou-Mrad, Nassib Elia, Aniella Abi-Gerges. Knowledge about and attitudes toward medical informed consent: a Lebanese population survey. Ethics & Behavior (2022) 34(2):89-103.
- Wared Nour-Eldine, Katia Sayyed, Zeina Harhous, Carole Dagher-Hamalian, Stephanie Mehanna, Donna Achkouti, Hanan ElKazzaz, Rony S. Khnayzer, Firas Kobeissy, Christian Khalil, Aniella Abi-Gerges. Gasoline fume inhalation induces apoptosis, inflammation, and favors Th2 polarization in C57BL/6 mice. Journal of Applied Toxicology (2022) 42(7):1178-1191.
- Rita Hanna, Wared Nour-Eldine, Youakim Saliba, Carole Dagher-Hamalian, Pia Hachem^, Pamela Abou-Khalil, Delphine Mika, Audrey Varin, Magali Samia El Hayek^, Laetitia Pereira, Nassim Fares, Gregoire Vandecasteele, Aniella Abi-Gerges. Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy. Life Sciences (2021) 283:119857
- Aniella Abi-Gerges, Liliana Castro, Jérôme Leroy, Valérie Domergue-Dupont, Rodolphe Fischmeister, Grégoire Vandecasteele. Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy. Journal of Molecular and Cellular Cardiology (2021) 150:109-121.
- Aniella Abi-Gerges, Carole Dagher-Hamalian, Pamela Abou-Khalil, Joe Braham Chahine^, Pia Hachem^, Christian Khalil. Evaluation of waterpipe smoke toxicity in C57BL/6 mice model. Pulmonary Pharmacology and Therapeutics (2020) 63:101940.
- Sassi Y, Abi-Gerges A, Fauconnier J, Hulot J-S. Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. Faseb Journal (2012) 26(3):1009-17.
- Leroy J, Richter W, Mika D, Abi-Gerges A, Fischmeister R, Vandecasteele G. Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ and protects against ventricular arrhythmias in mice. Journal of Clinical Investigation, (2011) 121(7):2651—2661.
- Abi-Gerges A, Richter W, Lefebvre F, Fischmeister R, Vandecasteele G. Decreased expression and activity cAMP phosphodiesterases in cardiac hypertrophy and its impact on ß-adrenergic cAMP signals. Circulation Research (2009) 105(8):784-92.
- Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechene P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G. Spatiotemporal dynamics of ß-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: Role of phosphodiesterases. Circulation Research (2008) 102: 1091-100.
- Rochais F, Abi-Gerges A, Horner K, Lefebvre F, Cooper DM, Conti M., Fischmeister R, Vandecasteele G. A specific pattern of phosphodiesterases controls the cAMP signals generated by Gs-coupled receptors in adult rat ventricular myocytes. Circulation Research (2006) 98, 1081-1088.
View Dr. Abi-Gerges’s publications on PubMed.
Professional and Research Interests
- Teaching of Human Physiology
- Teaching of Medical Ethics
- Research in Cellular and Molecular Cardiac Physiopathology:
- Characterization of cardiac Cyclic Adenosine 3′-5′ Monophosphate (cAMP) and Calcium signaling pathways in diabetic cardiomyopathy
- Characterization of congenital heart diseases in the Lebanese population
- Research in Medical Ethics:
- Review of the Lebanese Medical Ethics laws and their application among the medical community
- Assessment of the Lebanese population’s knowledge, attitude and behavior regarding the Lebanese Medical Ethics laws pertaining to medical informed consent
- Research on Public Health and Gender studies
Education
- Lebanese Baccalaureate: Emphasis on Experimental Sciences, Notre Dame de Mont Carmel, Lebanon, 1999
- Bachelor of Science in Biology: Emphasis on Cell Biology, Biochemistry, and Genetics, Saint Joseph University, Beirut, Lebanon, 2002
- Research Master’s degree in Cellular Physiopathology and Therapeutic Innovation, University of Paris 11, France, 2004
- Ph.D. in Cellular, Molecular and Cardiac Physiopathology, University of Paris 11, 2008
- Post-doctoral Fellowship, Pierre and Marie Curie University, Paris, 2008-2011
- Medical Ethics Diploma, Lebanese University, Lebanon, 2019
- Center for Innovating Learning Faculty Fellows Program, Lebanese American University, 2021
Awards and Grants
- Grant for Research Master’s degree from the “Service des Relations Internationales”, University of Paris 11, France, 2003-2004
- Post-graduate grant award from the French Ministry of Research, 2004-2007
- Post-graduate award from the “Groupe de Réflexion sur la Recherche Cardiovasculaire” (G.R.R.C), France, 2007-2008
- National Council for Scientific Research (CNRS) and Lebanese American University, 2018-2020: Characterization of cAMP signaling pathway in diabetic cardiomyopathy: Interplay between PDEs, MRP4 and Epac.
- Partenariat Hubert Curien franco-libanais - PHC CEDRE, 2019-2020: Rôle des régulateurs de la voie β-adrénergique dans la cardiomyopathie diabétique et les arythmies.
- LAU President’s Intramural Research Fund, 2022-2024: Effects of waterpipe smokes on cardiac cyclic adenosine 3’-5’ monophosphate (cAMP) signaling and the major actors of the cardiac excitation contraction coupling (ECC) in diabetic cardiomyopathy (DCM).
Public Exposure
جهد أنيلا أبي جرجس بأخلاق الطب وحرّية المريض (almodon.com)
The Lebanese Physician’s podcast:
https://www.youtube.com/watch?si=BgH-PNlRkRuDeYRB&v=3Pyp0bEkrBo&feature=youtu.be
Keywords
Human Physiology, Cell Physiology, Medical Ethics, Research, Basic Sciences, Cardiac Physiology, Cardiac Pathophysiology, Diabetic Cardiomyopathy, Heart Failure, Congenital Heart diseases, Cell Signaling, Cardiopulmonary diseases, In vivo studies, Gender studies